Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells
Daniela De Stefanis 1 , Patrizia Reffo, Gabriella Bonelli, Francesco M Baccino, Giuseppina Sala, Riccardo Ghidoni, Patrice Codogno, Ciro Isidoro Affiliation 1 Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy. PMID: 12222689 DOI: 10.1515/BC.2002.106 Abstract Ceramide has been suggested as an important mediator of apoptosis. In HT-29 colorectal cancer cells increased ceramide levels, induced by exogenous N-acetylsphingosine (NAS,…