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The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds – Additional weapons in the fight against the COVID-19 pandemic?

di ciro_isidoro

Andréa D Fuzimoto  1 , Ciro Isidoro  2   Affiliations 1 Holistic Sync – Holistic Integrative Medicine, USA/Brazil. 2 Dipartimento di Scienze della Salute, Università “A. Avogadro”, Novara, Italy.   PMID: 32691005 PMCID: PMC7260130 DOI: 10.1016/j.jtcme.2020.05.003   Review: J Tradit Complement Med. 2020 May 30;10(4):405-419. doi:  10.1016/j.jtcme.2020.05.003. eCollection 2020 Jul.   Abstract Introduction: As of March…

Differential effects of thymoquinone on lysophosphatidic acid-induced oncogenic pathways in ovarian cancer cells

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Ji Hee Ha  1   2 , Muralidharan Jayaraman  1   2 , Rangasudhagar Radhakrishnan  1 , Rohini Gomathinayagam  1   2 , Mingda Yan  1 , Yong Sang Song  3 , Ciro Isidoro  4 , Danny N Dhanasekaran  1   2   Affiliations 1 Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. 2 Department…

Curative effect of xanthohumol supplementation during liver fluke-associated cholangiocarcinogenesis: Potential involvement of autophagy

di ciro_isidoro

Suyanee Thongchot  1   2   3 , Malinee Thanee  1   3 , Watcharin Loilome  1   3 , Anchalee Techasen  3   4 , Thidarat Boonmars  3   5 , Prakasit Sa-Ngiamwibool  3   6 , Attapol Titapun  3   7 , Puangrat Yongvanit  3 , Ciro Isidoro  2 , Nisana Namwat  1   3   Affiliations 1 Department of Biochemistry, Faculty…

Preconditioning-induced cytoprotection in hepatocytes requires Ca(2+)-dependent exocytosis of lysosomes

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Rita Carini  1, Roberta Castino, Maria Grazia De Cesaris, Roberta Splendore, Marina Démoz, Emanuele Albano, Ciro Isidoro   Affiliation 1 Laboratory of Pathology, Dipartimento di Scienze Mediche, Università del Piemonte Orientale A. Avogadro, via Solaroli 17, 28100 Novara, Italy. PMID: 14970255 DOI: 10.1242/jcs.00923 J Cell Sci. 2004 Mar 1;117(Pt 7):1065-77. doi: 10.1242/jcs.00923. Epub 2004 Feb 17.   Abstract A short period…

Destination ‘lysosome’: a target organelle for tumour cell killing?

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Roberta Castino  1 , Marina Démoz, Ciro Isidoro   Affiliation 1 Dipartimento di Scienze Mediche, Università degli Studi del Piemonte Orientale ‘A Avogadro’, Novara, Italy. PMID: 14523947 DOI: 10.1002/jmr.643 Review: J Mol Recognit. Sep-Oct 2003;16(5):337-48. doi: 10.1002/jmr.643.   Abstract Lysosomes and lysosome-related organelles constitute a system of acid compartments that interconnect the inside of the cell with…

Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D

di ciro_isidoro

Marina Démoz  1 , Roberta Castino, Patrizia Cesaro, Francesco M Baccino, Gabriella Bonelli, Ciro Isidoro   Affiliation 1 Dipartimento di Scienze Mediche, Università A Avogadro, Novara, Italy. PMID: 12437111 DOI: 10.1515/BC.2002.137 Biol Chem. Jul-Aug 2002;383(7-8):1237-48. doi: 10.1515/BC.2002.137.   Abstract In several ‘in vitro’ models of apoptosis, lysosomal proteolysis has been shown to play an active role in mediating the death…

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